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Ono Clinic
Ono Neurosurgical and Medical Clinic is a private practice, offering community-based and compassionate care in Nagareyama, Chiba, Japan.
The clinic specializes in disorders of the nervous system.
This includes diseases of the brain, spinal cords, nerves, and muscles.
Special doctors with qualification of neurosurgery boards serve as a consultant to other physicians as well as providing long-term care to patients with chronic neurological disorders.
Common problems that we will diagnose and treat are
★ Headaches
★ Vertigo or dizziness
★ Numbness or hyperesthesia
★ Strokes
★ Seizures (epilepsy)
★ TIA (transient ischemic attack)
★ Chronic pain
★ Parkinson's disease
★ Dementias (including Alzheimer)
★ Various sequelae following head and neck trauma
The clinic is equipped with MRI, MAGNETOM ESSENZA, the established performer at 1.5T, which is indispensable for diagnosis and assessment of neurological diseases.
Computed Radiography (CR) with X-ray examinations, ECG, and Electric Patient Charts are also available at the clinic.
Director
Nobuo ONO, M.D., Ph.D.
Dr. Ono received his medical degree from Gunma University, School of Medicine in 1978, when he worked as a postdoctoral fellow at Neuroradiology Department in Johns Hopkins University, Baltimore, Maryland, U.S.A. He obtained ECFMG (Educational Commission for Foreign Medical Graduates) in 1979. He continued his medical training at Department of Neurosurgery, Gunma University, followed by residency at Saitama Cancer Center and Yamanashi Prefectural Central Hospital. As a qualified neurosurgeon, he also worked at OR (operating rooms) and ER (emergency rooms) of Fukaya Red Cross Hospital, National Takasaki Hospital, and Saku General Hospital. He completed his Ph.D. in 1990. From 1994, He worked as a visiting professor at Neurosurgery Department in Rush Presbyterian Saint Luke's Medical College, Chicago, Illinois, U.S.A. From 1996 to 2002, he was the head of Neurosurgery at Horie Hospital. He worked for the Neurology Clinic and Rehabilitation Rooms at Kobari General Hospital, just before he opens Ono Clinic.
List of Academic Publications achieved by
Nobuo Ono, M.D., Ph.D.
Contributions to scientific journals are:
1) Ono N, et al: Diatrizoate distribution in dogs as a function of administration rate and time following intravenous injection. J Comput Assist Tomogr (New York) 4:174-177, 1980
2) Uematsu S, Hendler N, Hungerford D, Long DM, Ono N: Thermography and electromyography in the differential diagnosis of chronic pain syndromes and reflex sympathetic dystrophy. J Electromyogr Clin Neurophysiol (U.S.A.) 21:165-182, 1981
3) Ono N, et al: Vasospasm following removal of large pituitary adenoma by the subfrontal approach. Neurol Med Chir (Tokyo) 21:609-614, 1981 (Abstract in English)
4) Koizumi H, Ono N, et al: Computed tomography in meningeal carcinomatosis. Progress in CT (Tokyo) 4:199-204, 1982 (Abstract in English)
5) Ono N, et al: A suprasellar embryonal carcinoma producing alpha-fetoprotein and human chorionic gonadotropin; treated with combined chemotherapy followed by radiotherapy. Surg Neurol (New York) 18:435-443, 1982
6) Zama A, Ono N, et al: Computed tomography in intra-orbital tumors. Saitama Med J (Saitama, Japan) 17:931-938, 1983 (Jpn)
7) Ono N, et al: Successful treatment of a basilar aneurysm presenting as a brainstem hemorrhage. Surg Neurol (New York) 22:365-370, 1984
8) Ono N, et al: Clinical significance of short-term cerebral aneurysmal enlargement. Neurol Med Chir (Tokyo) 25:534-540, 1985
9) Tamura M, Inoue H, Nakamura M, Yamazaki H, Kunimine H, Ono N: Cerebral hemorrhage from unexpected intracranial tumors. Neurol Med Chir (Tokyo) 25:620-625, 1985 (Abstract in English)
10) Ono N, et al: Germ cell tumor in the basal ganglia: Immunohistochemical demonstration of alpha-fetoprotein, human chorionic gonadotropin, and carcinoembryonic antigen. Surg Neurol (New York) 25:495-500, 1986
11) Ono N, et al: Diagnosis of germinal neoplasm in the thalamus and basal ganglia. Surg Neurol (New York) 26:24-28, 1986
12) Inoue HK, Kunimine H, Zama A, Ono N: Clinical pathology of primitive gliomas in the cerebrum. Acta Neurochir (Wien) 81:94-99, 1986
13) Nakamura M, Inoue K, Ono N, et al: Analysis of hemangiopericytic meningiomas by immunohistochemistry, electron microscopy and cell culture. J Neuropathol Exp Neurol (U.S.A.) 46:57-71, 1987
14) Inoue HK, Naganuma H, Ono N: Pathobiology of intracranial germ-cell tumors: Immunochemical, immunohistochemical and electron microscopic investigations. J Neuro-oncol (Netherlands) 5:105-115, 1987
15) Tamura M, Inoue K, Kunimine H, Nakamura M, Ono N: Clinicopathological study of high-dose fractionated radiation therapy in the treatment of glioblastoma. Neurol Med Chir (Tokyo) 28:367-72,1988 (Abstract in English)
16) Ono N, et al: Primary intracranial germ cell tumors. Kitakanto Med J (Gunma, Japan) 39:657-671, 1989 (Abstract in English)
17) Tamura M, Nakamura M, Kunimine H, Ono N, et al: Large dose fraction radiotherapy in the treatment of glioblastoma. J Neuro-oncol (Netherlands) 7:113-119, 1989
18) Tamura M, Ono N, et al: Adjunctive treatment of recurrent childhood ependymoma of the fourth ventricle: chemotherapy with CDDP and MCNU. Child's Nerv Syst (Italy) 6:186-189, 1990
19) Ono N, et al: Congenital gliosarcoma; so-called sarcoglioma. Child's Nerv Syst (Italy) 6:416-420, 1990
20) Tamura M, Ono N, et al: Treatment of medulloblastoma with extraneural metastases: adjunct chemotherapy with CDDP and MCNU. Nerv Syst Child (Kobe, Japan) 15:391-395, 1990 (Abstract in English)
21) Tamura M, Nakamura M, Ono N: Remote metastasis of intracranial meningioma. Clinicopathological study of four cases. Brain Tumor Pathol (Nagoya, Japan) 7:39-47, 1990 (Abstract in English)
22) Ono N, et al: Cerebrospinal fluid placental alkaline phosphatase in the intracranial germinomas. Results of enzyme antigen immunoassay. Neurol Med Chir (Tokyo) 31:563-567, 1991
23) Adachi J, Ono N, et al: Multiple liver metastases of a suprasellar germ cell tumor treated with combined chemotherapy of cisplatin and etoposide. Neurol Surg (Japan) 19:671-675,1991 (Abstract in English)
24) Inoue H, Nakamura M, Sakamoto K, Koga H, Ono N: Recent progress in the management of mass lesions of the thalamus and basal ganglia in children. Nerv Syst Child (Kobe, Japan) 16:277-283, 1991 (Abstract in English)
25) Ono N, et al: Suprasellar germinomas; relationship between tumour size and diabetes insipidus. Acta Neurochir (Wien) 114:26-32, 1992
26) Inoue HK, Nakamura M, Ono N, et al: Ultrastructure of hypothalamic hamartoma. Med Electron Microsc (Tokyo) 25:5-6, 1992
27) Ono N, et al: Long-term survivors in children treated for medulloblastomas and germinomas. Pediatr Oncol(Tokyo)29:140-143,1992 (Jpn)
28) Tamura M, Ono N, et al: Small gliomas. Clinicopathological study. Neurol Med Chir (Tokyo) 33:425-428, 1993
29) Inoue HK, Kamagata M, Negishi T, Yoshida T, Kobayashi S, Kakegawa T, Kohga H, Ono N: Surgical treatment of spinal cord injury. Prevention of secondary damage in the acute stage and functional restoration in the chronic stage. Kitakanto Med J (Gunma, Japan) 43:399-404, 1993 (Abstract in English)
30) Ono N, et al: A case of suprasellar germinoma mimicking a granuloma of histiocytosis X. Neurosurg Letter (Tokyo) 3:941-945, 1993 (Abstract in English)
31) Tamura M, Ono N, et al: Delayed brain hemorrhage associated with prophylactic whole brain irradiation for pediatric malignant brain tumor: a case report. Child's Nerv Syst (Italy) 9:300-301, 1993
32) Inoue HK, Nakamura M, Ono N, et al: Radiosensitive squamous cell craniopharyngioma: clinial and pathological comparison with the adamantinomatous type. Brain Tumor Pathol (Nagoya, Japan) 10:27-31,1993
33) Tamura M, Ono N, et al: Surgical results of brain metastasis from lung cancer. Kitakanto Med J (Gunma, Japan) 43:525-529, 1993 (Abstract in English)
34) Inoue HK, Nakamura M, Ono N, et al: Long-term clinical effects of radiation therapy for primitive gliomas and medulloblastomas: a role for radiosurgery. Stereotact Funct Neurosurg (Switzerland) 61 (suppl):51-58, 1993
35) Ono N, et al: Factors affecting functional prognosis in survivors of primary central nervous system germinal tumors. Surg Neurol (New York) 41:9-15, 1994
36) Kano T, Zama A, Ono N, et al: A juvenile case of radiation-induced meningioma two years after radiation for craniopharyngioma. Neurol Surg (Japan) 22:367-370,1994 (Abstract in English)
37) Tamura M, Shibasaki T, Horikoshi S, Ono N: Small gliomas: metabolism and blood flow. Neurol Med Chir (Tokyo) 34:91-94, 1994.
38) Ono N, et al: Recurrence of primary intracranial germinomas after complete response with radiotherapy: recurrence patterns and therapy. Neurosurgery (U.S.A.) 35:615-620, 1994
39) Ono N, et al: Brain tumor recurrence and ocurrence in children with growth hormone therapy. Pediatr Oncol (Tokyo) 31:15-18, 1994 (Jpn)
40) Inoue HK, Kohga H, Zama A, Ono N, et al: Differentiation potential in medulloblastomas and primitive gliomas. – An ultrastructural study – Med Electron Microsc (Tokyo) 27:1-7, 1994
41) Tamura M, Ono N, et al: Changes of the bromodeoxyuridine labeling index of astrocytic tumors between primary and recurrent lesions. Brain Tumor Pathol (Nagoya, Japan) 11:173-176, 1994
42) Inoue HK, Kohga H, Kakegawa T, Ono N, et al: Radiosensitive craniopharyngiomas: The role of radiosurgery. Acta Neurochir (suppl, Wien)62:43-46, 1994
43) Inoue HK, Kohga H, Nakamura M, Ono N, et al: Long-term follow-up study of conventional irradiation for brain tumours in children: A role for radiosurgery. Acta Neurochir (suppl, Wien) 62:83-87, 1994
44) Imai H, Ono N, et al: Diagnosis and treatment of brainstem abscess using magnetic resonance imaging and microsurgical aspiration. Neurol Med Chir (Tokyo)35:160-164, 1995
45) Kanazawa H, Ono N, et al: Partial resection of hypothalamic hamartoma. A long-term follow-up. Hormone Clin (Tokyo) 43:184-188, 1995 (Jpn)
46) Ono N, et al: Long-term intrathecal morphine infusion for intractable pain due to lumbar arachnoiditis, using a programmable implanted drug pump. Neurosurg Letter (Tokyo) 5:687-691, 1995 (Abstract in English)
47) Inoue HK, Nakamura M, Ono N, et al: The ultrastructure of atypical and anaplastic meningiomas. Med Electron Microsc 28:111-117, 1995
48) Tamura M, Kohga H, Ono N, et al: Calcified astrocytoma of the amygdalo-hippocampal region in children. Child's Nerv Syst (Italy) 11:141-144, 1995
49) Inoue HK, Kanazawa H, Kohga H, Zama A, Ono N, et al: Hypothalamic hamartoma: anatomic, immunohistochemical, and ultrastructural features. Brain Tumor Pathol 12: 45-51, 1995
50) Inoue HK, Kanazawa H, Kohga H, Ono N: Invasion of craniopharyngiomas. Hormone Clin (Tokyo) 43:150-154, 1995 (Jpn)
51) Tamura M, Shibasaki T, Horikoshi S, Zama a, Kurihara H, Ono N, et al: Histological and radioimaging study of malignant change in low-grade astrocytoma, in Nagai M (ed): Brain Tumor Research and Therapy. Springer-Verlag Tokyo, 1996, pp45-49.
52) Ono N, et al: A comparison of children with suprasellar germ cell tumors and craniopharyngiomas: final height, weight, endocrine, and visual sequelae after treatment. Surg Neurol 46:370-377, 1996
53) Kanazawa H, Fujimaki H, Kohga H, Ono N, et al: Pituitary apoplexy following TRH stimulation in an acromegaly patient. Hormone Clin (Tokyo) 44:82-85, 1996 (Jpn)
54) Zama A, Kohga H, Ono N, et al: An intra- and supra-sellar fibromyxoma-like tumor. Med Electron Microsc 29:129-136, 1996
55) Ono N, et al: Effects of intrathecal nonnarcotic analgesics on chronic tactile allodynia in rats: α2-agonists versus somatostatin analog. Neurol Med Chir (Tokyo) 37:6-11, 1997
56) Tamura M, Zama A, Kurihara H, Ono N, et al: Correlation between glioblastoma cell infiltration and T2 prolongation on magnetic resonance imaging. Neuropathology 17:186-188, 1997
57) Ono N, et al: Radiotherapy for craniopharyngioma in children under 10 years of age. Hormone Clin (Tokyo) 45:149-153, 1997 (Jpn)
58) Tamura M, Shibasaki T, Zama A, Kurihara H, Horikoshi S, Ono N, et al: Assessment of malignancy of glioma by positron emission tomography with 18F-fluorodeoxyglucose and single photon emission computed tomography with thallium-201 chloride. Neuroradiology 40:210-215, 1998
59) 小野伸夫：埋没型薬物ポンプによる疼痛の治療、高倉公朋監修：脳神経外科の最先端、先端医療技術研究所、東京、p22-27, 1999
60) Ono N, et al: Central precocious puberty following severe head injury. Nerv Syst Child (Japan) 26:72-75, 2001 (Abstract in English)
61) 小野伸夫、Penn RD：髄腔内薬物持続投与法、菊地晴彦監修：脊椎・脊髄外科の最前線、先端医療技術研究所、東京、p246-252. 2002
Published conference papers
(Proceedings and Abstracts) are:
62) Ono N, et al : Placental alkaline phosphatase as a tumor marker for germinomas. Neuropathol (Kyoto, Japan) 6: 222-223, 1985 (Jpn)
63) Zama A, Inoue HK, Kunimine H, Ono N: A case of undifferentiated glioma in the skull base. Shinshu Med J (Japan) 33:174-175,1985 (Jpn)
64) Ono N, et al: A case of infantile mixed glioma and sarcoma. Kitakanto Med J (Gunma, Japan) 39: 397-399, 1989 (Jpn)
65) Ono N, et al: Two cases of suprasellar granulomas. Niigata Med J (Niigata, Japan) 104:428-429, 1990 (Jpn)
66) Oshima Y, Sotomatu M, Suetake N, Shidara T, Kuroiwa M, Suzuki N, Matuyama S, Ono N: Two cases of choriocarcinoma. Pediatr Oncol (Tokyo) 27: 210-211, 1990 (Jpn)
67) Ono N, et al: Long-term sequelae after curative therapy of cerebral germ-cell tumors. J Cancer Res Clin Oncol Suppl 1 (Hamburg, Germany) 116: 405, 1990
68) Ono N, et al: Tumors of the thalamus and basal ganglia in children; Relationship between tumor site, histological differentiation and cerebral hemiatrophy. Pediatr Neurosurg (Switzerland) 16:108,1991
69) Imai H, Sasaguchi N, Hayase N, Zama A, Ono N, et al: Single photon emission tomography studies of cerebral lesions with ring-like enhancement on X-ray CT scan. J Gunma Nucl Med Forum (Gunma, Japan) 7:113-116, 1992 (Jpn)
70) Zama A, Tamura M, Shibasaki T, Ono N, et al: Effect of propentofylline on a patient presenting with aphasia, mental retardation and right hemiparesis caused by severe brain edema associated with meningioma. Age Disease (Tokyo) 6:535-539, 1993 (Jpn)
71) Zama A, Watanabe K, Imai H, Sasaguchi, Hayase N, Ono N, et al: A case of secretory meningioma. Niigata Med J (Japan) 107:843-844, 1993 (Jpn)
72) Imai H, Hayashi S, Ishiuchi S, Kohga H, Zama A, Ono N, et al: A case of olfactory neuroblastoma. Shinshu Med J (Japan) 42:243-244,1994 (Jpn)
73) Hirato J, Sasaki A, Iijima M, Yokoo H, Nakasato Y, Ono N, et al: A case of ependymoma with prominent intracytoplasmic vacuolations. Shinshu Med J (Matsumoto, Japan) 42:245-246, 1994 (Jpn)
74) Zama A, Tamura M, Nakamura M, Inoue HK, Ono N, et al: Fine structure and growth rate of endothelial cells of human gliomas. Brain Pathology 4:425, 1994
75) Ono N: Effect of insulin-like growth factor binding protein-1 on rat C6 glioma cells. Kitakanto Med J (Gunma, Japan) 46: 83, 1996 (Jpn)
76) Tamura M, Ono N, et al: Tumor cell invasion of glioblastoma in the high intensity area on T2 weighted MR images. Neuropathol (suppl, Tokyo) 16: 48, 1996 (Jpn)
77) Ono N, et al: Chronic pain model in rats induced by ligating spinal peripheral nerves, and the clinical application. Kitakanto Med J (Gunma, Japan) 46:175-176, 1996 (Jpn)
78) Inoue HK, Negishi M, Kohga H, Ono N, et al: Transcallosal approach to the interpeduncular cistern for large third ventricular tumors. Kitakanto Med J (Gunma, Japan) 47:193, 1997 (Jpn)
79) Tamura M, Ono N, et al: Comparison of MIB-1 staining index in various brain tumors. Neuropathol (suppl, Tokyo) 17: 160, 1997 (Jpn)
80) Kohga H, Inoue HK, Kanoh T, Fujimaki H, Ono N, et al: Gamma knife radiosurgery treatment strategies for pituitary adenoma in view of dose-response. Stereotactic Radiotherapy (Gunma, Japan) 1:63-69, 1997 (Jpn)
81) Ono N, et al: Case of central precocious puberty following severe head injury. Nerv Syst Child (Japan) 25:350, 2000 (Jpn)
82) 小野伸夫：堀江病院脳神経外科、医者がすすめる専門病院、山梨・栃木・群馬: 医療研究グループ編、ライフ企画、p323, 2001
83) Tosaka M, Hayashi S, Nagaya T, Ono N, et al: Germinoma presenting as extradural spinal metastasis. Kitakanto Med J (Gunma, Japan) 51:164, 2001 (Jpn)